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- 01Smallpox, introduced by a single enslaved man in Cortés's force, killed Aztec emperor Cuitláhuac and an estimated 40% of Tenochtitlan's population before the siege ended.
- 02Cortés blocked all three causeways out of the island city, destroyed the freshwater aqueduct from Chapultepec, and deployed brigantines on the lake.
- 03When the last emperor Cuauhtémoc was captured on August 13, 1521, Spanish soldiers reportedly waded through streets ankle-deep in corpses for three miles.